What is the Smallest Worthwhile Difference in Cardiovascular Risk?
Novel measure tested for public acceptance of statin therapy
Peter A. McCullough, MD, MPH
Feb 21, 2026
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The investigators applied an explicit decision-making metric—the Smallest Worthwhile Difference (SWD)—defined as the minimum absolute risk reduction in ASCVD events that individuals consider sufficient to justify long-term statin use.
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I’m on a statin and have been for awhile. Both my GP and cardio doc recommended it, back before the COVID craziness and I, along with a lot of people, lost confidence in Big Pharma and Big Medicine. Of course, no one should ever have any trust in Gooferment politicians and bureaucrats. During the interim after I started static, I’ve seen a lot of chatter about statins, side effects, and risks. Makes me less confident in the therapy.
BUT, (and there is always a BIG butt), I’ve gotten this far with their advice so I’ll stick with it. Concerned but befuddled.
YMMV (Your Mileage May Vary!)
As Sharyl says: “Do Your Own Research. Make Up Your Own Mind. Think For Yourself.” — Sharyl Attkisson
If you’re wrong, at least you make your own decision with “informed consent”.
I trust my car to an “expert”; in the absence of evidence to the contrary, I guess I’ll trust my doctors. For Now!
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